Rare disease clinical trials are constrained Hair Accessories to small sample sizes and may lack placebo-control, leading to challenges in drug development.This paper proposes a Bayesian model-based framework for early go/no-go decision making in rare disease drug development, using Duchenne muscular dystrophy (DMD) as an example.Early go/no-go dec
Nowadays, franchise is the way to do business at the fastest pace in the world.More than 600,000 franchise business activities are spread all over the American continent generating sales of one trillion dollars.Over 40% of the US retail trade in products and services are achieved by franchises.A new franchise opens somewhere in the US every 12 minu
One possible manifestation of multiple myeloma may be extramedullary plasmacytoma, manifested by infiltration of plasma cells outside the bone marrow.In the debut of the disease, bone plasmacytomas are most often diagnosed, in contrast to extramedullary ones, which are rare.According to the literature, the presence of extramedullary plasmacytoma is
Timothy H.Dixon.2017.Curbing Catastrophe: Natural Hazards and Risk Reduction in the Modern World.(New York, NY: Cambridge University Press) 300 pp.ISBN 978-1108113663.In Curbing Catastrophe, Timothy H.Dixon explores commonalities among natural disasters like Hurricane Katrina, the 2010 earthquake in Haiti, and the meltdown at Fukushima.He identifie
The liver is a vital organ involving in various major metabolic functions in human body.MicroRNA-122 (miR-122) plays an important role in the regulation of liver metabolism, but its intrinsic Laptop Accessories physiological functions require further clarification.This study integrated the genome-scale metabolic model of hepatocytes and mouse exper